XHANCE uses your own breath to reach the source of the problem—Nasal Polyps.

Frustrated by symptoms that won’t improve?

EXPERIENCE THE
DIFFERENCE

INDICATION
XHANCE is a prescription medicine used to treat nasal polyps in adults.

THE DIFFERENCE OF HIGH & DEEP

XHANCE has a mouthpiece, as well as a nosepiece. It is designed to use your own breath to help deliver medicine high and deep into the nasal passages.

XHANCE uses your breath to help reach the source of the problem

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps.

You blow into XHANCE, you don’t sniff. Your breath helps deliver medicine high and deep into your nasal passages, where nasal polyps occur. That means the medicine should reach the source of the problem.

Because you blow when you use XHANCE, you may also limit the medicine from dripping down your throat, so more medicine is directed to where it’s needed to help treat your symptoms.

XHANCE IS DESIGNED DIFFERENTLY

XHANCE has a nosepiece and a flexible mouthpiece, giving you a different way to deliver the medicine where it needs to go.

NOSEPIECE
FLEXIBLE
MOUTHPIECE
INDENTED
GRIP
BOTTLE
XHANCE has a nosepiece with a flexible mouthpiece.

SYMPTOM RELIEF WITHIN REACH

XHANCE is approved for the treatment of nasal polyps in adults. In clinical trials, XHANCE improved symptoms of nasal polyps, such as nasal congestion as early as 2 weeks, and symptoms continued to get better over time. In addition, XHANCE significantly reduced the size of nasal polyps over time. Regular use for several months may be needed for best results.

In 16-week clinical trials.

For nasal congestion

XHANCE REDUCED
NASAL CONGESTION

Runny nose or post-nasal drip

XHANCE REDUCED
NASAL POLYPS


For BEST RESULTS

Orange tick    Use XHANCE regularly, twice daily
Orange tick    Continue use as instructed by your doctor
Orange tick    Remember to refill your prescription monthly, or as prescribed by your physician

NASAL POLYPS AND THEIR SYMPTOMS

Nasal polyps result from chronic inflammation and can occur high and deep within your nasal passages and sinuses. This makes them difficult to see with a routine nasal exam. In fact, you may not even know you have nasal polyps.

The symptoms of nasal polyps last at least 3 months. Because nasal polyps and associated inflammation block passages high and deep in the nose, nasal sprays may have a hard time reaching them. That may be why you’re not getting the relief you need.

Nasal congestion that won’t improve. Learn more about the signs and symptoms of Nasal Polyps and associated inflammation.

SIGNS AND SYMPTOMS
OF NASAL POLYPS:

For nasal congestion Nasal congestion, Runny nose or post-nasal drip Runny nose/post-nasal drip For facial pain and pressuren Facial pain or pressure (usually in the nose and sinus region), Reduced sense of smell due to nasal congestion Reduced sense of smell

Talk to an ENT or Allergist to see if you may have nasal polyps.

TALK TO A SPECIALIST ABOUT YOUR SYMPTOMS

Patient questionnaire for XHANCE

Be sure to download and complete the Patient Questionnaire and bring it with you to your next appointment.

DOWNLOAD QUESTIONNAIRE >

HOW TO USE: SEAL, AIM, BLOW, PRESS

Watch this step-by-step video to get you into the flow of things

For full instructions on using XHANCE, please see Patient Information and Instructions for Use.


GETTING STARTED

Before using a new bottle of XHANCE for the first time, you have to prime it. Here’s how.

XHANCE has a nosepiece with a flexible mouthpiece. XHANCE has a one handed as well as a two handed grip. A new XHANCE must be primed. Follow these simple steps. Remove the cap and shake. Pump 7 times, or until you see a fine mist.

Note:
If you have not used XHANCE for 7 or more days, re-prime by spraying 2 times.

USING XHANCE

First shake. Then using one or two hands, place your fingers on the indented grip below the mouthpiece. Gently insert the mouthpiece into your nose to form a tight seal, then rotate to insert the flexible mouthpiece into your mouth while keeping the nosepiece deep in the nostril.

First, shake. Then, using 1 or 2 hands, place your fingers on the indented grip BELOW the mouthpiece. Gently insert the nosepiece into your nose and flexible mouthpiece into your mouth.

Keep a tight seal between the nosepiece and your nostril
Aim the device upward between your eyes.

Aim the device upward between your eyes.

It may help to use a mirror
Take a deep breath and blow into the mouthpiece. Imagine you are blowing up a balloon. Blow, don’t sniff and don’t block the other nostril.

Take a deep breath and blow hard into the mouthpiece. Imagine you are blowing up a balloon.

Blow, don’t sniff, and don’t block other nostril!
Keep blowing as you press the bottle with your thumb, releasing the medicine deep into your nasal passages. Keep blowing hard while pressing the bottle.

Keep blowing as you press the bottle with your thumb, releasing the medicine deep into your nasal passages.

Keep blowing hard while pressing the bottle
  • Repeat these steps for your other nostril

  • REMEMBER TO USE
    XHANCE TWICE DAILY

    (or as prescribed by your healthcare provider)

DID I DO IT RIGHT?

  • Shake before each use

  • Keep a snug fit in nose and mouth

  • Continue blowing hard while pressing the bottle

  • Do not sniff, inhale, or block second nostril

  • Administer only the prescribed number of sprays in each nostril

ELIGIBLE PATIENTS MAY RECEIVE XHANCE FOR AS LOW AS $0*

THE INFORMATION BELOW WILL SHOW YOU HOW TO GET YOUR XHANCE PRESCRIPTION and how you can save with the XHANCE Preferred Pharmacy Network.



*For eligible, commercially insured patients. Terms and conditions apply.



USING THE XHANCE PREFERRED PHARMACY NETWORK

When you use the XHANCE Preferred Pharmacy Network, you can save on your prescriptions. And you can get them delivered directly to you.

If your commercial insurance:

Covers XHANCE


$0 copay for the first prescription

$0 copay for refills with the Refill Program

$30 copay per unit or less for refills not in the Refill Program

Orange line

Does not cover XHANCE


$0 copay for the first prescription

$50 copay per unit maximum or less for refills


Get Started Today

Download the XHANCE Preferred Pharmacy Network form and bring it to your ENT or Allergist. If you don't have an ENT or Allergist, click "Find a Specialist" to look for one near you.



Find a Network Pharmacy to Ship Your Prescription


If your commercial insurance:

Covers XHANCE


$0 copay for your first prescription with the XHANCE Copay Card

$30 copay per unit for refills with the XHANCE Copay Card

Orange line

Does not cover XHANCE


At this time, eligible patients can only receive savings for XHANCE through the Preferred Pharmacy Network. Find a network pharmacy above.

If you would like to use your own pharmacy, be sure to bring your XHANCE Copay Card to receive the most savings.

Download Copay Card >

Do you want to pay out of pocket?

$100 off each prescription with the XHANCE Copay Card

Download Copay Card >
Orange line

Do you need assistance paying for XHANCE?

Up to 6 months of XHANCE at no cost to qualifying patients

Patient Assistance Program

1-833-4XHANCE



FAQs

YOU HAVE QUESTIONS. WE HAVE ANSWERS.

UNDERSTANDING NASAL POLYPS
How do I know if I have nasal polyps?

Nasal polyps result from chronic inflammation and occur high and deep within your nasal passages. This makes them difficult to see with a routine nasal exam. In fact, you may not even know you have nasal polyps.

Symptoms of nasal polyps last at least 3 months and include nasal congestion and 1 (or more) of the following:

  • Runny nose or post-nasal drip
  • Facial pain or pressure (usually in the nose or sinus region)
  • Loss of sense of smell or taste

Talk to an ENT or Allergist to find out if you have nasal polyps. They can diagnose nasal polyps by examining the inside of your nose, often with the use of a special scope.

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps. XHANCE is a different kind of nasal spray—it uses your own breath to help deliver medicine high and deep into nasal passages, the source of the problem.

In clinical trials,* XHANCE improved the symptoms of nasal polyps, such as nasal congestion, as early as 2 weeks, which continued to get better over time.

In addition, XHANCE significantly reduced the size of nasal polyps.

*In 16-week clinical trials.

Yes. XHANCE and Flonase are different products. While both contain the same active ingredient (fluticasone propionate), XHANCE uses an Exhalation Delivery System to carry medicine high and deep into the nose. In addition, XHANCE has a different formulation and strength.

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps, which carries the medicine high and deep into the nose. Flonase has not been FDA-approved for the treatment of nasal polyps.

Flonase is a registered trademark of the GSK group of companies.

No. XHANCE is free of alcohol, fragrances, dyes, gluten, and lactose.

For step-by-step instructions on how to use XHANCE, watch the XHANCE How to Use Video.
And remember these tips:

  1. Shake the device before each use.
  2. Make sure it fits snugly in your nose and mouth.
  3. Continue to blow hard while pressing the bottle.
  4. Administer only the prescribed number of sprays in each nostril.

For full instructions on how to use XHANCE, please see the FDA-approved Instructions for Use.

You only need to prime XHANCE before your first use. Simply remove the cap, shake, and press the bottle 7 times into the air (away from your face) or until you see a fine mist.

If you have not used XHANCE for 7 or more days, re-prime by spraying twice.

After correctly inserting the XHANCE mouthpiece and nosepiece, exhale through your mouth like you are blowing up a balloon. While continuing to blow, use your thumb to press up on the bottle. This will release the medicine into your nostril so that it reaches high and deep into your nose.

Please visit the How to Use section for step-by-step instructions.

You may not feel the medicine going in because XHANCE uses your breath to help deliver the medicine high and deep into your nose. This does not mean that your device is not working correctly.

XHANCE works differently than other nasal sprays. When you exhale into the device, your soft palate creates a natural seal, that may limit the amount of medicine that can drip down your throat. As a result, medicine is directed to where it is needed to help treat your symptoms.

Yes; after using XHANCE in 1 nostril, repeat the same steps for the other nostril.

Always use XHANCE exactly as your healthcare provider tells you to. The recommended dose for XHANCE is 1 spray per nostril twice a day. Taking XHANCE as prescribed—without missing doses—is an important part of reaching your treatment goals. For full details on how to use XHANCE, see the FDA-approved Instructions for Use.

If you miss a dose of XHANCE, take it as soon as you remember the same day. Do not take more than your prescribed dose of XHANCE each day.

In clinical trials, XHANCE was shown to be safe in studies lasting up to 1 year. Your prescriber will help you determine how long you should be on XHANCE.

The most common side effects of XHANCE include:

  • nosebleeds
  • sores in your nose
  • pain or swelling of the nose or throat (nasopharyngitis)
  • redness in the nose
  • nasal congestion
  • sinus infection
  • headache

These are not all of the side effects associated with XHANCE. Call your doctor for medical advice about side effects, or see the full Prescribing Information. You may report side effects to OptiNose at 1-833-678-6673 or the FDA at 1-800-FDA-1088.

XHANCE is a prescription medication used to treat nasal polyps in adults. Your healthcare provider will determine if XHANCE is right for you.

Before using XHANCE, tell your healthcare provider about all of your medical conditions and medications you are taking.

Do not use XHANCE if you are allergic to fluticasone propionate or any of the other ingredients in XHANCE. See the Patient Information for a complete list of ingredients in XHANCE.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

XHANCE and certain other medicines may interact with each other. This may cause side effects.

It’s important to tell your healthcare provider if you take antifungal or anti-HIV medicines.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Yes. XHANCE can be used on the go and is convenient for travel. However, it is recommended that you keep XHANCE in its original packaging, especially if taking it on a flight. Check the TSA website for rules and regulations in your area regarding medications.

You do not need to clean XHANCE. If you’d prefer to clean the device, remove the cap and use a clean, dry, lint-free cloth to wipe.

The XHANCE bottle is made of glass and can be damaged if dropped or hit too hard. If you drop or hit XHANCE, call 1.833.678.6673. Do not use if damaged.

To make sure that your device is working correctly, follow these steps:

  • First, check that there is medicine (liquid) in the bottle
  • Then, prime the device (if you have not yet primed it). To prime the device, hold it away from your face and press the bottom part of the bottle with the label at least 7 times or until you see a fine mist

XHANCE includes a preservative that prevents bacterial growth.

XHANCE provides 120 sprays, which will last 30 days at 1 spray per nostril twice a day. If it is prescribed as 2 sprays per nostril twice a day, XHANCE will last 15 days.

Throw XHANCE away after using 120 sprays after initial priming. Even though the bottle may not be completely empty, you may not get the correct dose of medicine if you continue to use it.

XHANCE is available by prescription, so you must speak to your healthcare provider to see if XHANCE is right for you.

If you use the XHANCE Preferred Pharmacy Network, you may get XHANCE for as low as $0, if you are an eligible commercially insured patient. And you can have your prescription delivered right to you. Go to How to Get XHANCE and Save to find out more.

If you want to save on XHANCE, use the XHANCE Preferred Pharmacy Network. Commercially insured, eligible patients can get XHANCE for as low as $0. Find out more by going to How to Get XHANCE and Save.

If you don't have insurance, call 1-833-4XHANCE or visit our Patient Assistance Program for information about how you can save.

RESOURCES

Make the most out of your next doctor visit. Find out if XHANCE is right for you.
XHANCE Patient Questionnaire

If you think you may have nasal polyps, please feel free to download this short questionnaire and answer a few simple questions about your symptoms. Then share it with your ENT or Allergist to see if XHANCE is right for you.

Download Questionnaire >
The printable brochure provides step-by-step visual instructions on using XHANCE.
XHANCE Brochure

This printable brochure provides information about nasal polyps, XHANCE and step-by-step instructions about using XHANCE.

XHANCE copay savings card. Eligible commercially insured patients can pay as little as $0 for their first 30-day prescription. For eligible patients. Terms and conditions apply.
XHANCE Copay SAVINGS Card

Download the XHANCE Copay Savings Card and save on your prescription of XHANCE.*

For eligible, commercially insured patients. Terms and conditions apply.

Download Copay Savings Card >
This useful tool will help you find a specialist in your area who is familiar with treating nasal polyps.
NEED A SPECIALIST?

This useful tool will help you to find a specialist in your area who is familiar with treating nasal polyps.

CLICK HERE TO FIND ONE >

IMPORTANT SAFETY INFORMATION

INDICATION

XHANCE is a prescription medicine used to treat nasal polyps in adults.

IMPORTANT SAFETY INFORMATION

  • Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE. Get emergency medical care if you get any of these signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, or low blood pressure. 
  • Tell your healthcare provider about all your medical conditions and medications that you take. It is especially important to mention if you take antifungal or anti-HIV medicines as they may interact with XHANCE.
  • XHANCE can cause nasal problems such as nosebleeds, crusting, sores, hole in the septum, and slow wound healing.
  • XHANCE can cause eye problems including glaucoma and cataracts. You should have regular eye exams when using XHANCE. 
  • XHANCE may increase the risk of infections and can make certain infections worse. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE.
  • XHANCE can cause reduced production of steroid hormones by your adrenal gland, resulting in tiredness, weakness, nausea and vomiting, and low blood pressure. 
  • XHANCE can weaken bones (osteoporosis).
  • Other side effects may include redness, pain, or swelling of the nose or throat, thrush (fungal infection of the nose and throat), nasal congestion, sinus infection and headache. These are not all the side effects of XHANCE. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see Patient Information, full Prescribing Information, and Instructions for Use.