XHANCE uses your own breath to reach the source of the problem—Nasal Polyps.

Frustrated by symptoms that won’t improve?

EXPERIENCE THE
DIFFERENCE

INDICATION
XHANCE is a prescription medicine used to treat nasal polyps in adults.

THE DIFFERENCE OF HIGH & DEEP

XHANCE has a mouthpiece, as well as a nosepiece. It is designed to use your own breath to help deliver medicine high and deep into the nasal passages.

XHANCE uses your breath to help reach the source of the problem

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps.

You blow into XHANCE, you don’t sniff. Your breath helps deliver medicine high and deep into your nasal passages, where nasal polyps occur. That means the medicine should reach the source of the problem.

Because you blow when you use XHANCE, you may also limit the medicine from dripping down your throat, so more medicine is directed to where it’s needed to help treat your symptoms.

XHANCE IS DESIGNED DIFFERENTLY

XHANCE has a nosepiece and a flexible mouthpiece, giving you a different way to deliver the medicine where it needs to go.

NOSEPIECE
FLEXIBLE
MOUTHPIECE
INDENTED
GRIP
BOTTLE
XHANCE has a nosepiece with a flexible mouthpiece.

SYMPTOM RELIEF WITHIN REACH

XHANCE is approved for the treatment of nasal polyps in adults. In clinical trials, XHANCE improved symptoms of nasal polyps, such as nasal congestion as early as 2 weeks, and symptoms continued to get better over time. In addition, XHANCE significantly reduced the size of nasal polyps over time.

In 16-week clinical trials.

For nasal congestion

XHANCE REDUCED
NASAL CONGESTION

Runny nose or post-nasal drip

XHANCE REDUCED
NASAL POLYPS

NASAL POLYPS AND THEIR SYMPTOMS

Nasal polyps result from chronic inflammation and occur high and deep within your nasal passages and sinuses. This makes them difficult to see with a routine nasal exam. In fact, you may not even know you have nasal polyps.

The symptoms of nasal polyps last at least 3 months. Because nasal polyps and associated inflammation block passages high and deep in the nose, nasal sprays may have a hard time reaching them. That may be why you’re not getting the relief you need.

Nasal congestion that won’t improve. Learn more about the signs and symptoms of Nasal Polyps and associated inflammation.

SIGNS AND SYMPTOMS
OF NASAL POLYPS:

For nasal congestion Nasal congestion, Runny nose or post-nasal drip Runny nose/post-nasal drip For facial pain and pressuren Facial pain or pressure (usually in the nose and sinus region), Reduced sense of smell due to nasal congestion Reduced sense of smell

Talk to an ENT or Allergist to see if you may have nasal polyps.

TALK TO A SPECIALIST ABOUT YOUR SYMPTOMS

Patient questionnaire for XHANCE

Be sure to download and complete the Patient Questionnaire and bring it with you to your next appointment.

DOWNLOAD QUESTIONNAIRE >

HOW TO USE: SEAL, AIM, BLOW, PRESS

Watch this step-by-step video to get you into the flow of things

For full instructions on using XHANCE, please see Patient Information and Instructions for Use.


GETTING STARTED

Before using a new bottle of XHANCE for the first time, you have to prime it. Here’s how.

XHANCE has a nosepiece with a flexible mouthpiece. XHANCE has a one handed as well as a two handed grip. A new XHANCE must be primed. Follow these simple steps. Remove the cap and shake. Pump 7 times, or until you see a fine mist.

Note:
If you have not used XHANCE for 7 or more days, re-prime by spraying 2 times.

USING XHANCE

First shake. Then using one or two hands, place your fingers on the indented grip below the mouthpiece. Gently insert the mouthpiece into your nose to form a tight seal, then rotate to insert the flexible mouthpiece into your mouth while keeping the nosepiece deep in the nostril.

First, shake. Then, using 1 or 2 hands, place your fingers on the indented grip BELOW the mouthpiece. Gently insert the nosepiece into your nose and flexible mouthpiece into your mouth.

Keep a tight seal between the nosepiece and your nostril
Aim the device upward between your eyes.

Aim the device upward between your eyes.

It may help to use a mirror
Take a deep breath and blow into the mouthpiece. Imagine you are blowing up a balloon. Blow, don’t sniff and don’t block the other nostril.

Take a deep breath and blow hard into the mouthpiece. Imagine you are blowing up a balloon.

Blow, don’t sniff, and don’t block other nostril!
Keep blowing as you press the bottle with your thumb, releasing the medicine deep into your nasal passages. Keep blowing hard while pressing the bottle.

Keep blowing as you press the bottle with your thumb, releasing the medicine deep into your nasal passages.

Keep blowing hard while pressing the bottle
  • Repeat these steps for your other nostril

  • REMEMBER TO USE
    XHANCE TWICE DAILY

    (or as prescribed by your healthcare provider)

DID I DO IT RIGHT?

  • Shake before each use

  • Keep a snug fit in nose and mouth

  • Continue blowing hard while pressing the bottle

  • Do not sniff, inhale, or block second nostril

  • Administer only the prescribed number of sprays in each nostril

FAQs

YOU HAVE QUESTIONS. WE HAVE ANSWERS

UNDERSTANDING NASAL POLYPS
How do I know if I have nasal polyps?

Nasal polyps result from chronic inflammation and occur high and deep within your nasal passages. This makes them difficult to see with a routine nasal exam. In fact, you may not even know you have nasal polyps.

Symptoms of nasal polyps last at least 3 months and include nasal congestion and 1 (or more) of the following:

  • Runny nose or post-nasal drip
  • Facial pain or pressure (usually in the nose or sinus region)
  • Loss of sense of smell or taste

Talk to an ENT or Allergist to find out if you have nasal polyps. They can diagnose nasal polyps by examining the inside of your nose, often with the use of a special scope.

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps. XHANCE is a different kind of nasal spray—it uses your own breath to help deliver medicine high and deep into nasal passages, the source of the problem.

In clinical trials,* XHANCE improved the symptoms of nasal polyps, such as nasal congestion, as early as 2 weeks, which continued to get better over time.

In addition, XHANCE significantly reduced the size of nasal polyps.

*In 16-week clinical trials.

Yes. XHANCE and Flonase are different products. While both contain the same active ingredient (fluticasone propionate), XHANCE uses an Exhalation Delivery System to carry medicine high and deep into the nose. In addition, XHANCE has a different formulation and strength.

XHANCE is the only FDA-approved prescription nasal spray that uses an Exhalation Delivery System to treat nasal polyps, which carries the medicine high and deep into the nose. Flonase has not been FDA-approved for the treatment of nasal polyps.

Flonase is a registered trademark of the GSK group of companies.

No. XHANCE is free of alcohol, fragrances, dyes, gluten, and lactose.

To use XHANCE, you blow into it—you don’t sniff. This helps to deliver the medicine high and deep into your nasal passages to reach nasal polyps where they originate.

You should take a deep breath and blow hard into the mouthpiece. It is important not to sniff and not to block the other nostril.

Watch the XHANCE How to Use Video for step-by-step instructions. For full instructions on using XHANCE, please see the FDA-approved Instructions for Use.

You only need to prime XHANCE before your first use. Simply remove the cap, shake, and press the bottle 7 times into the air (away from your face) or until you see a fine mist.

If you have not used XHANCE for 7 or more days, re-prime by spraying twice.

After correctly inserting the XHANCE mouthpiece and nosepiece, exhale through your mouth like you are blowing up a balloon. While continuing to blow, use your thumb to press up on the bottle. This will release the medicine into your nostril so that it reaches high and deep into your nose.

Please visit the How to Use section for step-by-step instructions.

XHANCE works differently than other nasal sprays. When you exhale into the device, your soft palate creates a natural seal, that may limit the amount of medicine that can drip down your throat. As a result, medicine is directed to where it is needed to help treat your symptoms.

Yes; after using XHANCE in 1 nostril, repeat the same steps for the other nostril.

Always use XHANCE exactly as your healthcare provider tells you to. The recommended dose for XHANCE is 1 spray per nostril twice a day. Taking XHANCE as prescribed—without missing doses—is an important part of reaching your treatment goals. For full details on how to use XHANCE, see the FDA-approved Instructions for Use.

If you miss a dose of XHANCE, take it as soon as you remember the same day. Do not take more than your prescribed dose of XHANCE each day.

In clinical trials, XHANCE was shown to be safe in studies lasting up to 1 year. Your prescriber will help you determine how long you should be on XHANCE.

The most common side effects of XHANCE include:

  • nosebleeds
  • sores in your nose
  • pain or swelling of the nose or throat (nasopharyngitis)
  • redness in the nose
  • nasal congestion
  • sinus infection
  • headache

These are not all of the side effects associated with XHANCE. Call your doctor for medical advice about side effects, or see the full Prescribing Information. You may report side effects to OptiNose at 1-833-678-6673 or the FDA at 1-800-FDA-1088.

XHANCE is a prescription medication used to treat nasal polyps in adults. Your healthcare provider will determine if XHANCE is right for you.

Before using XHANCE, tell your healthcare provider about all of your medical conditions and medications you are taking.

Do not use XHANCE if you are allergic to fluticasone propionate or any of the other ingredients in XHANCE. See the Patient Information for a complete list of ingredients in XHANCE.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

XHANCE and certain other medicines may interact with each other. This may cause side effects.

It’s important to tell your healthcare provider if you take antifungal or anti-HIV medicines.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

Yes. XHANCE can be used on the go and is convenient for travel. However, it is recommended that you keep XHANCE in its original packaging, especially if taking it on a flight. Check the TSA website for rules and regulations in your area regarding medications.

You do not need to clean XHANCE. If you’d prefer to clean the device, remove the cap and use a clean, dry, lint-free cloth to wipe.

The XHANCE bottle is made of glass and can break if dropped or hit too hard. If you accidentally drop XHANCE, check it for damage. Return it to your pharmacist if the device is damaged or the bottle is broken.

XHANCE includes a preservative that prevents bacterial growth.

XHANCE provides 120 sprays, which will last 30 days at 1 spray per nostril twice a day. If it is prescribed as 2 sprays per nostril twice a day, XHANCE will last 15 days.

Throw XHANCE away after using 120 sprays after initial priming. Even though the bottle may not be completely empty, you may not get the correct dose of medicine if you continue to use it.

XHANCE is available by prescription, so you must speak to your healthcare provider to see if XHANCE is right for you. XHANCE is available at most local pharmacies and for added convenience through any of our Preferred Pharmacies who will mail XHANCE directly to your door.

The XHANCE Xtended Patient Support program is available to help eligible commercially insured patients save on XHANCE. To learn more about this program, call us at 1-833-XHANCE1.

Additionally, you can download the XHANCE Copay Savings Card. This card may help eligible commercially insured patients get XHANCE for as little as $0 for their first 30-day prescription.* If your local pharmacy asks you to pay more than $50 per unit call 1-833-4XHANCE.

See terms and conditions and eligibility rules.

RESOURCES

Make the most out of your next doctor visit. Find out if XHANCE is right for you.
XHANCE Patient Questionnaire

Make the most out of your next doctor visit! Download this short questionnaire, answer a few simple questions about your symptoms, and then share it with your ENT or Allergist to see if XHANCE is right for you.

Download Questionnaire >
The printable brochure provides step-by-step visual instructions on using XHANCE.
XHANCE How to use brochure

This printable brochure provides step-by-step visual instructions on using XHANCE.

Download Brochure >
XHANCE copay savings card. Eligible commercially insured patients can pay as little as $0 for their first 30-day prescription. For eligible patients. Terms and conditions apply.
XHANCE Copay SAVINGS Card

Download the XHANCE Copay Savings Card and save on your prescription of XHANCE.*

For eligible patients. Terms and conditions apply.

Download Copay Savings Card >
This useful tool will help you find a specialist in your area who is familiar with treating nasal polyps.
NEED A SPECIALIST?

This useful tool will help you to find a specialist in your area who is familiar with treating nasal polyps.

CLICK HERE TO FIND ONE >