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XHANCE is a prescription medicine used to treat chronic rhinosinusitis with or without nasal polyps in adults. It is not known if XHANCE is safe and effective in children.

Important Safety Information

  • Do not use XHANCE if you are allergic to fluticasone propionate or any of the ingredients in XHANCE. Get emergency medical care if you get any of these signs of a serious allergic reaction: rash, hives, swelling of your face, mouth, and tongue, breathing problems, or low blood pressure.
  • XHANCE can cause nasal problems such as nosebleeds, crusting, sores, hole in the septum, and slow wound healing. You should not use XHANCE until your nose has healed if you have a sore on your nose, have had surgery on your nose, or if your nose is injured.
  • XHANCE can cause eye problems including glaucoma and cataracts. You should have regular eye exams when using XHANCE. Call your doctor if you have vision changes while using XHANCE.
  • XHANCE may increase the risk of infections and can make certain infections worse. Avoid contact with people who have a contagious disease such as chickenpox or measles while using XHANCE.
  • XHANCE can cause reduced production of steroid hormones by your adrenal gland, resulting in tiredness, weakness, nausea and vomiting, and low blood pressure.
  • XHANCE can weaken bones (osteoporosis).
  • The most common side effects include: nose bleeds, sores (ulcers) in your nose, pain or swelling of your nose or throat, redness in your nose, nasal congestion, sinus infection and headache.
  • Tell your healthcare provider about all your medical conditions and medications that you take. It is especially important to mention if you take antifungal or anti-HIV medicines as they may interact with XHANCE.

These are not all the side effects of XHANCE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA at or call 1-800-FDA-1088.

Please see Patient Information, full Prescribing Information and Instructions for Use.